Specific research projects include:
Enzyme Catalysis: understanding enzyme catalysis, including reactive intermediates. Applications in inhibitor discovery and biocatalyst development for green biotransformations.
Protein-Protein Interactions: identification of cyclic peptide inhibitors of protein-protein interaction using a genetically encoded high-throughput screening platform; applications in cell biology, including cancer.
Post-translational Modifications: understanding the mechanisms of ubiquitin and its related enzymes, and carbohydrate processing enzymes.
Lipidomics: to explore the effect of reduced dimensionality and molecular crowding on the properties of complex reaction networks (and in particular biochemical reaction networks).
BioNanoPhotonics: expertise in Raman spectroscopy, molecular and chemical imaging, fabrication and characterisation of metallic nanomaterials for plasmonics. Application of spectroscopy to neuroscience, pulmonary diseases and regenerative medicine